Structure of the benthic polychaetes community, collected on soft bottoms of Mánamo creek, was analyzed. Samples were taken with an Eckman dredge and sifted on a sieve of 0.5 mm mesh size. Four hundred-ten specimens were examined and twenty-four polychaete species were identified. Families with the greatest number of organisms were Capitellidae and Spionidae with four species each, Nephtys bucera was the dominant species throughout the study and was present at all sampling stations. Diversity index values ranged between 1.17 and 3.44 bits.ind-1. Polychaeta’s community was significantly different among areas (F= 3.37, p<0.05) and it also varied significantly among sites of these areas (F= 2.90, p<0.05). Despite having found low richness values, this work is a significant contribution to the knowledge of species diversity in the Orinoco delta region and on the dynamics of this community, based on their distribution throughout the system, being in this case mainly driven by a salinity gradient
